In addition to the Marine Corps' combat assault mission, the H-46 Sea Knight is used by the Navy and Marine Corps for search and rescue, and by the Navy for vertical replenishment at sea and for Special Warfare. Boeing delivered 624 H-46s to the Navy and the Marines from 1964 to 1971. Today the Marines operate 232 H-46Es and 9 H-46Ds. The Navy operates 69 H-46Ds.

The U.S. Marine Corps retired the CH-46 Sea Knight in August 2015.